Opera CRO attended Vitafoods Europe 2018

Opera CRO, a TIGERMED company, attended at the global nutraceutical event “Vitafoods Europe – 2018”.

Vitafoods Europe is the most focused event in the world dedicated to ingredients and raw materials for the nutraceutical, functional food and drink and nutricosmetics industries.

Opera CRO presented three posters. Two of them are related to food supplements containing hyaluronic acid for the treatment of knee osteoarthritis and the last is about the efficacy and tolerability of a new food supplement in controlling hyperglycaemia and hypertriglyceridemia in patients with elevated LDL.

For further information, please access the following links:

  1. Oral hyaluronan for the treatment of knee osteoarthritis: a systematic review;
  2. Oral hyaluronic acid administration for knee osteoarthritis;
  3. Efficacy and tolerability of a new oral nutraceutical (Liposcudil® BBR) in controlling hyperglycaemia and hypertriglyceridemia in patients with elevated LDL.

Don’t Fry Day!

Skin cancer, caused by too much sun, is the most common of all cancers. More people will be diagnosed with skin cancer this year than breast, prostate, lung, and colon cancer combined. The National Council on Skin Cancer Prevention reminds you to enjoy the outdoors safely. They have named this Friday „Don’t Fry Day”.

What you can do to be safe in the sun:

  1. Avoid sun tanning and tanning beds. Ultraviolet (UV) light from tanning beds and the sun causes skin cancer and wrinkling;
  2. Cover up. Wear protective clothing, such as a long-sleeved shirt, pants, a wide-brimmed hat, and sunglasses, where possible;
  3. Seek shade/use umbrellas. Remember that the sun’s UV rays are strongest between 10 a.m. and 4 p.m.;
  4. Generously apply sunscreen to all exposed skin using a Sun Protection Factor (SPF) of at least 30 that provides broad-spectrum protection from both UVA and UVB rays. Reapply every two hours, even on cloudy days, and after swimming or sweating;
  5. Use extra caution near water, snow and sand because they reflect the damaging rays of the sun, which can increase your chance of sunburn;
  6. Get vitamin D safely through a diet that includes vitamin supplements and foods fortified with vitamin D. Don’t seek the sun or indoor tanning.


More details can be found on the official website.

Meet us at Vitafoods Europe 2018

Opera CRO, a TIGERMED company, will be present at Vitafoods Europe 2018.

„Vitafoods is a premium event within the nutraceutical industry where key players come together to share knowledge, overcome challenges and create business opportunities.”

Follow Vitafoods Europe 2018 official website for other details.

Meet us at DIA Europe 2018


17-19 April 2018 – BASEL, SWITZERLAND

Opera CRO, a TIGERMED company, will be present at DIA Europe 2018. Meet us @ Tigermed Exhibition Booth No. 105

“DIA is a global association that mobilizes life science professionals from across all areas of expertise to engage with patients, peers and thought leaders in a neutral environment on the issues of today and the possibilities for tomorrow.”

Follow DIA Europe 2018 official webpage for meeting programme and other details.

Download the Exhibition Floorplan here (or click on the image below)


Timisoara breaks all the preconceptions you can have about Romania

“Timisoara looks like the business card of Romania.

A city that breaks all the preconceptions one can have about Romania. In Timisoara, the houses are renovated, the streets are paved, there is full employment.

In the meantime, there are so many jobs here that the companies could grow much faster, there would not be any shortages of labor now. in Timisoara, wages are now around 500 euros on average, but they are rising rapidly.

The tax is in Romania at a flat rate of 16 percent, people are well-trained, can speak foreign languages. In Timisoara the entrepreneurs say they have never had to pay a cent as bribe to an official.”

Find out more interesting facts about Timisoara reading the full german article on Stern’s official website

How Romania became a popular tech destination

“At first glance Romania seems an unlikely base for cutting-edge tech start-ups. Even regular visitors associate it with misty mountains, medieval churches and potholed roads.

But many reasons seemed to confirm that Romania’s science-savvy workforce, a sizeable and growing domestic market, and EU membership make it a promising European destination for tech investors.”

Find out more on this interesting article posted by FINANCIAL TIMES


New Adjuvant Treatment for Breast Cancer approved by FDA

HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2), which promotes the growth of cancer cells. This type of breast cancer is more aggresive than other types of breast cancer.

The drug neratinib (Nerlynx, Puma Biotechnology) was approved by the US Food and Drug Administration as an adjuvant of the treatment of HER2-positive breast cancer.

According to a pivotal phase 3 randomized clinical trial performed on 2840 patients with early stage HER2-positive breast, the 1 year  administration of neratinib led to a disease-free survival rate of 94.2%, comparable with 91,9% at patients treated with placebo. Patients received the study drug and placebo after the treatment with trastuzumab.

The pharmacological action of neratinib is determined by the inhibition of tyrosine kinase and it works by blocking several enzyme that promote the grown of the cancer cells.

More information can be found here.

Proton-pumps inhibitors (PPIs) may be linked to an increased risk of death

Proton-pump inhibitors (PPIs) are widely use for controlling stomach acid and they are available for sale without prescription in many countries.

According to a new clinical study performed by Yan Xie, PhD, from the Clinical Epidemiology Center, Research and Education Service, Veterans Affairs Saint Louis Health Care System in Missouri, and colleagues, use of PPIs can lead to increased risk of death. They analyzed data for more than 6 million people for nearly 6 years — until 2013 or death. Three comparison groups were analyzed: first group, PPIs vs histamine-2 (H2)–blockers, second group  PPI users vs non-users and third group, patients receiving neither PPIs nor H2-blockers.


The results have shown that use of PPIs is associated with  increased risk of death compared with use of H2 blockers or no known exposure to any acid suppression therapy.

For more information, please access the full text article.


Development of new antibiotics

Antibiotics resistance represents one of the biggest problems of global health. Many infections, such as tuberculosis, pneumonia and gonorrhoea are harder to treat because the antibiotics used for their treatment become less effective.

In order to reduce the antibiotic resistance, European Medicines Agency (EMA), Food and Drug Administration (FDA) and Japanese Pharmaceutical and Medical Devices Agency (PMDA) encourage the clinical development of new antimicrobial agents. During the meeting in Vienna, the representatives from the three regulatory agencies have discussed about the design of new clinical trials for testing new treatments for several bacterial infections.

For more information please access European Medicines Agency website.

The effects of chocolate in cognitive function improvement

Nowadays, decline of cognitive function represents a major health issue and new studies are focused on the detection of preventive agents for cognitive decline and dementia.

Interest in nutraceuticals and functional food has increased in last years. Cocoa represents a rich source of flavonoids, a class of nutraceuticals with polyphenolic structure and several effects on human health, like cardioprotection, neuroprotection, and neuromodulation. Flavonols have antioxidant properties, meaning that they have the ability to reduce the effects of cell damage caused by oxidative stress.

According to a new review published in the journal Frontiers in Nutrition, by Valentina Socci and her colleagues from University of L’Aquila in Italy cognitive function could be improved within few hours after cocoa flavonols consumption. Furthermore, it was found that regular, long-term intake of cocoa flavonols protects againts cognitive decline.

For more information please access the full review article here.